Long time no see. For example you want to sent an automatic email in ASP.NET. But your culture is "en-GB" and the language of the person you want to email is Spanish("es-ES"). Then you want to use the Spanish resource files, while creating the mailMessage. You can use the Spanish resource file by using the HttpContext.GetGlobalResour... method. Dim sLabel As String = HttpContext.GetGlobalResour... "myKey", New CultureInfo("es-ES")) More information: http://msdn.microsoft.com/e... ......